Resumo

GUERRERO-ROJAS, Rafael  e  GUERRERO-FONSECAZ, Carlos. Molecular mechanisms of heat shock proteins (HSPs) involved in neoplasm development. Salud, Barranquilla [online]. 2018, vol.34, n.2, pp.455-474. ISSN 0120-5552.  https://doi.org/10.14482/sun.34.2.616.98.

The heat shock proteins (HSPs) are induced by cells stress and expressed at high levels in a broad range of tumors between including breast, lung, prostate, colon, leukemia and stomach cancer; this overexpression is closely associated with resistance to established therapies instituting a poor prognosis. The HSPs are involved in all cancer stages, from the proliferation, anti-apoptosis, even in invasion and metastasis. Within the mechanisms described by which the HSPs increased tumor aggressiveness and metastasis in some tumor types are evasion of apoptotic stimuli and immune response, loss of p53 function, increased expression of the proto-oncogenes HER2 and c-Myc, activation of plasmin and MMP2, all crucial to tumorigenesis. Thus, the HSPs have become targets for anti-cancer drug design and immunotherapy strategies.

Palavras-chave : Heat shock proteins; cancer; neoplasm growth; antitumor; oncogenesis.

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