Best regards from the editorial team of the Revista Colombiana de Gastroenterología, we are pleased to be able to communicate with you on a permanent basis to provide you with new information. This time, we would like to present to you this supplement, named Clinical Cases in Gastroenterology and Digestive Endoscopy, as a publication of the first semester of 2021 in our Journal.

One of the purposes of good practices in journal publishing is to avoid the obsolescence of the contents of articles submitted to be considered in the editorial process; thus, taking into account the large number and importance of clinical case reports submitted to our journal, we wanted them to have a timely publication in a special issue. This supplement contains 20 very interesting and entertaining clinical cases to be read, enjoyed and shared, which, hopefully, give rise to concerns and exchange of knowledge among colleagues.