Resumo

MENDOZA-MENDOZA, Deibie Yesith; SOTO-TIRADO, Susana  e  CARABALLO-CORDOVEZ, César. Clinical and epidemiological round: journal club. Iatreia [online]. 2018, vol.31, n.4, pp.419-428. ISSN 0121-0793.  https://doi.org/10.17533/udea.iatreia.v31n4a10..

In this new edition of the Clinical and Epidemiologic Round, the reader will find four articles that we have considered of special relevance for current clinical practice. In a pragmatic, multicenter and randomized controlled trial, Myles et al compared a restrictive versus liberal intravenous-fluid strategy for patients undergoing major abdominal surgery evaluating disability-free survival after one year. Furthermore, Mørch et al, present a Danish prospective cohort evaluating the association between the use of oral contraceptives and risk of invasive breast cancer. Additionally, in a community-based cohort study, Lazarus et al aimed to quantify the association between metformin use and hospitalization with acidosis across the range of estimated glomerular filtration rate. At last, using a mendelian randomization study, Mountjoy et al aimed to determine whether more years spent in education is a causal risk factor for myopia or, conversely, whether myopia is a causal risk factor for more years in education.

Palavras-chave : Breast Neoplasms; Chronic Kidney Disease; Contraception; Education; Fluid Therapy; Lactic Acidosis; Metformin; Myopia; Postoperative Complications; Risk Assessment; Survival Rate.

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