Resumo

ROSERO, Doris Amanda  e  DEL CORRAL, Helena. Contribution of M. tuberculosis IS6110 based RFLP assay to the design and refinement of tuberculosis control strategies in Colombia. Infect. [online]. 2008, vol.12, n.3, pp.175-191. ISSN 0123-9392.

Molecular biology methods offer an alternative for improving tuberculosis control strategies through M. tuberculosis strain typing techniques. The international literature shows that RFLP of the insertion element IS6110 is widely standardized internationally and has proved to be a useful tool to guide local tuberculosis control strategies. By means of a thorough literature review, this study aimed to determine if this molecular based method could be useful for the design and refinement of tuberculosis control strategies in Colombia. Results from epidemiologic studies published between 1995 and 2008 which used this technique in developing countries, including Colombia, were analyzed. Our results suggest that in the Colombian context this molecular technique can provide useful information for tuberculosis program control directors and therefore it should continue to be performed. However, to establish periodicity, target populations and other aspects related to optimal conditions for accurate RFLP performance, must await further evidence from operational research studies including cost effectiveness and cost utility analyses.

Palavras-chave : Mycobacterium tuberculosis; RFLP- IS6110; tuberculosis control; Colombia.

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