SciELO - Scientific Electronic Library Online

 
vol.16 número1Influência dos programas coletivos na condição física de mulheres idosasCaracterização e sintomas de pacientes colombianos com neoplasias mieloproliferativas índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

  • Em processo de indexaçãoCitado por Google
  • Não possue artigos similaresSimilares em SciELO
  • Em processo de indexaçãoSimilares em Google

Compartilhar


Revista Ciencias de la Salud

versão impressa ISSN 1692-7273

Resumo

SOBREIRA DANTAS NOBREGA DE FIGUEIREDO, Francisco Rodolpho et al. Assessment of Modulatory and Cytotoxic Activity of the Essential Oil in Hyptis Martiusii Benth Leaves. Rev. Cienc. Salud [online]. 2018, vol.16, n.1, pp.49-58. ISSN 1692-7273.  https://doi.org/10.12804/revistas.urosario.edu.co/revsalud/a.6489.

Introduction:

The species Hyptis martiusii Benth. commonly called "cidreira do campo" has multiple biological properties, such as antifungal, anti-inflammatory, and insecticide. The aim of this study was to investigate the modulating activity of the essential oil of the fresh leaves of Hyptis martiusii in association with different antibiotics against the bacteria Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, as also the cytotoxic activity of this species.

Materials and methods:

The study used the MIC (minimum inhibitory concentration) as a way of assessing the modulation using an inoculation of 100 microliters of each bacterial strain. The cytotoxicity tests were conducted using in vitro culture of mouse connective tissue cells (fibroblasts of mammals).

Results:

The research demonstrated that the essential oil from leaves of Hyptis martiusii Benth (OEHM) presented synergism only when associated with the antibiotics gentamicin and imipenem against the bacteria Pseudomonas aeruginosa and Escherichia coli. However, it presented antagonism in association with amikacin, gentamicin and imipenem against the three studied bacteria. In addition to the ciprofloxacin showed no relevant results. In relation to the cytotoxic activity the lethal concentration (LC50) exhibited a value of 263.12 [ig/ml.

Conclusion:

Ultimately it was established, that H. Martiusii presents a synergistic cytotoxic activity against the evaluated bacteria.

Palavras-chave : Antibacterial activity; cytotoxic activity; cidreira do campo; Hyptis martiusii; essential oil.

        · resumo em Português | Espanhol     · texto em Português     · Português ( pdf )