Resumo

MARTINEZ, Cristina Isabel; PEREZ, Luis Francisco; BAQUERO, David  e  BARCO, Andrés. Hereditary colorectal cancer not associated with polyposis or Lynch syndrome. rev. colomb. cir. [online]. 2017, vol.32, n.4, pp.297-303. ISSN 2011-7582.  https://doi.org/10.30944/20117582.38.

Hereditary nonpolyposis colorectal cancer, also known as Lynch syndrome is recognized as an autosomal dominant hereditary syndrome of incomplete penetrance characterized by mutations in DNA repair genes. It is the most frequent of all the hereditary syndromes, and increases the likelihood of developing colorectal cancer, thus representing 2-3% of all colorectal cancers (CRC). This syndrome predisposes to metachronous (CRC) and other extracolonic cancers, as endometrium, small bowel, ureter and renal pelvis, among others. Therefore, it is necessary to recognize this syndrome and identify individuals with HNPCRC to prevent, diagnose and provide, if possible, early treatment in an effort to decrease its morbidity and mortality.

Palavras-chave : Colonic neoplasms; rectal neoplasms; neoplastic syndromes; hereditary; colorectal neoplasms; hereditary nonpolyposis; Lynch syndrome; primary prevention.

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