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Revista Med
versão impressa ISSN 0121-5256versão On-line ISSN 1909-7700
Resumo
URIBE HERRERA, Ana M.; ROJAS, Angela P.; REYES HARKER, Patricia e RODRIGUEZ LOPEZ, Martha L.. Development of Anthelminthic Drugs: Update on Drug Candidates and Therapeutic Targets in the Management of Soil-Transmitted Helminthiasis. Rev. Med [online]. 2022, vol.30, n.2, pp.9-22. Epub 10-Nov-2023. ISSN 0121-5256. https://doi.org/10.18359/rmed.6465.
It is estimated that 1.5 billion people worldwide are Infected with some soil-transmitted helminth (STH). The decreasing efficacy of anthelminthic drugs used In preventive chemotherapy, particularly reported for the species Trichuris trichiura, motivates the search for alternative anthelminthic agents to address this situation and prevent potential drug resistance within this drug class.
Objectives:
This review focuses on understanding the current state of research on therapeutic targets and drug candidates reported in the literature from 2013 to 2021.
Results:
Information from 28 research studies, covering developments from in silico phase to clinical research, was compiled. Most studies involved advancements in omics sciences, ranging from genome annotation corrections to the Identification of protein families crucial for pathogenic mechanisms.
Conclusion:
The information regarding drug targets and candidates presented in this review serves as a foundation for further exploration of potential applications and experimental development of these drugs for controlling soil-transmitted helminthiasis.
Palavras-chave : anthelmintics; uncinada; trichuriasis; ascarlasls, pharmacological targets.
