Resumo

ALVAREZ ALDANA, Adalucy; SEPULVEDA ARIAS, Juan Carlos  e  SILLER LOPEZ, Fernando. HUMAN PAPILLOMA VIRUS-INDUCED CARCINOGENESIS. Investig. andina [online]. 2012, vol.14, n.24, pp.438-456. ISSN 0124-8146.

Introduction: carcinogenesis is the process by which a normal cell transforms into a cancer cell and involves multiple steps which reflect genetic alterations that lead to the progressive transformation of normal tissue to malignant states. Viruses have been associated with cancer development in both animals and humans. Human Papilloma viruses (HPV) are related with the development of cervical cancer, considered the second more prevalent type of cancer in women worldwide. In this review we describe the events responsible for the HPV-induced carcinogenesis. Methods: a systematic literature search was conducted in Medline database. Results: this review discusses the relationship between infection and cancer, with emphasis on the HPV-induced carcinogenesis and the molecules involved in this process. Conclusions: E6 and E7 oncoproteins are essential in the process of malignant transformation induced by HPV and involve many other factors such as the interaction of these proteins with cell cycle regulatory factors.

Palavras-chave : Cervix; Neoplasia; Human Papilloma virus; Carcinogenesis.

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