Evaluation of the cytotoxic and leishmanicidal activity of extracts and fractions of Piper cumanense and Piper holtonii

Sánchez-Suárez, Jeysson; Albarracín, Diego; Rojas, Maritza; Rincón, Javier; Robledo, Sara; Muñoz, Diana Lorena; Oviedo, Jairo José; Calderón, Martha Nancy; Fernández, Nelson; Delgado, Gabriela

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Revista Colombiana de Ciencias Químico - Farmacéuticas

Print version ISSN 0034-7418On-line version ISSN 1909-6356

Abstract

SANCHEZ-SUAREZ, Jeysson et al. Evaluation of the cytotoxic and leishmanicidal activity of extracts and fractions of Piper cumanense and Piper holtonii. Rev. colomb. cienc. quim. farm. [online]. 2010, vol.39, n.1, pp.21-29. ISSN 0034-7418.

Piper genusá species are reported as promissory as tropical diseases treatment. This research showed the cytotoxic and leishmanicidal activity of extracts and fractions of different polarity derived from Piper cumanense (P. cumanense) and Piper holtonii (P. holtoni) on murine macrophages J774 and L. panamensis promastigotes (MHOM/ CO/87/UA140). Hexanic fraction (PcH) exhibited leishmanicidal effect with 2-fold index selectivity in this in vitro model used. These results suggest a potential antileishmanial activity which should be more studied.

Keywords : antileishmanial; Leishmania panamensis; in vitro assays; Piperaceae.

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